5/28/2024 0 Comments Synergy home care normal il![]() Brown, PhD Using models of autoimmunity and immune-suppression, the work in our laboratory is targeted toward understanding the natural history of viral infections and aberrant immune function common to inflammatory-mediated chronic diseases. Our broad objective is to synthesize regenerative scaffolds that, when implanted, stimulate recruitment and osteoblastic differentiation of the patient’s mesenchymal stem cells, leading to accelerated bone regeneration.Įlizabeth E. In complementary studies, we are developing novel methods for improving the bonding of bioactive proteins and peptides to bone-mimetic scaffolds. To further enhance the osteoinductive properties of the substrates, the matrices are being functionalized with tissue regenerative factors such as PDGF and BMP-2. The composite scaffolds produced by our group support robust mesenchymal stem cell survival and proliferation, and also stimulate substantial new bone formation when implanted into bone defects. The goal of this project is to create bone-like synthetic matrices for bone regeneration using technologies such as electrospinning and 3D printing. The broad goal of our research is to elucidate the mechanistic basis for sialylation-dependent receptor signaling, and to determine whether manipulating sialylation levels can be used as a clinical treatment for pathologies such as autoimmune disorders and metastatic cancer. In the case of tumor cells, upregulation of ST6Gal-I confers a cancer stem cell phenotype, and accelerates metastatic progression in animal models. Collectively these molecular pathways direct intracellular signaling cascades that regulate the migration and survival of both immune cells and epithelial tumor cells. Using cell model systems and genetically engineered mice, we have shown that ST6Gal-I-mediated sialylation controls the function of select integrins, growth factor receptors and death receptors. Our laboratory has determined that the ST6Gal-I glycosyltransferase adds a sialic acid to a distinct subset of receptors, thereby imparting an undifferentiated cell phenotype. Role of receptor glycosylation in conferring a stem-like, apoptosis-resistant cell phenotype Bellis, PhD The Bellis laboratory has two principal areas of research interest: Hubert Tse, PhD, Department of Microbiology Matthew Stoll, MD, PhD, MSCS, Division of Pediatric Rheumatology Lewis Zhichang Shi, MD, PhD, Department of Radiation Oncology ![]() Jan Novak, PhD, Department of MicrobiologyĬhander Raman, PhD, Department of Medicine Kabarowski, Ph.D., Department of Microbiology Hui-Chen Hsu, PhD, Department of Medicine Duncan, MD, Medicine/Division of Pulmonary, Allergy & Critical Care MedicineĬharles O. Susan Bellis, PhD, Department of Cell, Developmental and Integrative BiologyĮlizabeth Brown, PhD, MPH, Department of Pathology Clicking on the name at the beginning of the brief description links to their detailed personal website. For a brief description of their research interests, click on their name in the list. Faculty active in this area of research are listed below.
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